化合物 T14203 T14203

Product Introduction
Bioactivity


英文名: AM-8735

描述: AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).

体外活性: AM-8735 exhibits a dose-dependent increase of p21 mRNA, a direct transcriptional readout of p53 activity, in HCT116 p53wt cells (IC50=160 nM)[1]. AM-8735 displays substantial growth inhibition of wild-type p53 cells (IC50=63 nM) and no growth inhibition of p53-deficient cells (IC50>25 μM).

体内活性: AM-8735 shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with an ED50 of 41 mg/kg[1]. AM-8735 also demonstrates significant time and concentration dependent p21 mRNA induction in vivo in a pharmacodynamic assay in SJSA-1 osteosarcoma tumors.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: AM8735 | AM-8735 | AM 8735

相关产品: NVP-CGM097 | MG-277 | MX69 | Ganoderic acid X | Serdemetan | UC2288 | p53-Mdm2 inhibitor 4 | PhiKan 083 | RO-5963 | Navtemadlin

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途