BETA-淀粉样蛋白片断25-35 T14284

Product Introduction
Bioactivity


英文名: β-Amyloid (25-35)

描述: β-Amyloid (25-35) (Aβ25-35) 是一种阿尔茨海默氏淀粉样蛋白β肽的Aβ(25-35) 片段，在培养细胞中显示出神经毒性作用。

体外活性: β-Amyloid (25-35) 的氨基酸序列为NH2-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-COOH，首个Gly代表第25个氨基酸，末尾的Met代表第35个氨基酸。本研究首次探讨了该多肽在凝胶状态下的特性。研究表明，Amyloid beta-peptide(25-35)能够对分离出的脑线粒体产生凋亡效应，其中methionine-35的氧化还原状态对于程序性细胞死亡途径及其毒性事件的诱导起着关键作用[2]。同时，通过振动吸收光谱和ECD进行了比较研究。此外，利用振动吸收光谱和VCD光谱技术也对Aβ(25-35)多肽膜的构象偏好进行了探究[1]。

体内活性: The Alzheimer' s disease (AD) model group present with spatial learning and memory impairments. CDS and donepezil administration significantly ameliorate the Aβ25–35 peptide-induced memory impairment in both Morris water maze (P?
存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 3.33 mg/mL (3.14 mM)
DMSO : 97 mg/mL (91.49 mM)


关键字: β-amyloid peptide | Ab25-35 | Amyloid beta-peptide | b-Amyloid | Abeta | Abeta25-35 | inhibit | Inhibitor | β-Amyloid | Amyloid b-peptide | Amyloid-β | beta-Amyloid peptide | βAmyloid (2535) | β Amyloid (25 35) | b-Amyloid peptide | Amyloid β-peptide | beta-Amyloid | β-Amyloid peptide

相关产品: FPS-ZM1 | δ-secretase inhibitor 11 | γ-Secretase-IN-1 | ARN2966 | RAGE antagonist peptide acetate | (Rac)-Z-Phe-Phe-FMK | Aftin-4 | Latrepirdine dihydrochloride | Saikosaponin C | V-9-M Cholecystokinin nonapeptide

相关库: Bioactive Compounds Library Max | Human Metabolite Library | Peptide Compound Library | Anti-Alzheimer's Disease Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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