化合物AX-15836 T14360

Product Introduction
Bioactivity


英文名: AX-15836

描述: AX-15836是一种选择性 ERK5抑制剂，IC50值为8 nM。

体外活性: AX15836 was completely ineffective (EC50>10 μM) to suppress inflammatory cytokine response, suggesting that it was the BRD inhibition component of the compounds that mediated cytokine reduction. AX-15836 shows more than 1,000-fold selectivity for ERK5 over a panel of over 200 kinases and it also shows similar intracellular potency (4–9 nM) across all cells tested, including peripheral blood mononuclear cells (PBMCs), endothelial cells, and oncogenic cell lines. It also exhibits selectivity over BRD4 with a Kd of 3,600 nM. In HUVEC and HeLa cell types, samples treated with AX15836 shows very few genes to be differentially expressed. AX15836 could clearly inhibit the EGF-stimulated, phosphorylated form of ERK5 in HeLa cells[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (154.14 mM)


关键字: Extracellular signal regulated kinases | ERK | AX 15836 | inhibit | AX15836 | Inhibitor | AX-15836

相关产品: FR 180204 | Nyasol | Cajanin | Methylthiouracil | PERK-IN-3 | Tetrahydrocoptisine | NVP 231 | 7,8-Didehydrocimigenol | Lup-20(29)-en-28-oic acid | Zeylenone

相关库: Anti-Aging Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Colorectal Cancer Compound Library | Anti-Obesity Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library

化合物AX-15836 T14360信息由TargetMol中国为您提供，如您想了解更多关于化合物AX-15836 T14360报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途