化合物AZD4320 T14376

Product Introduction
Bioactivity


英文名: AZD4320

描述: AZD4320 是一种BCL2/BCLxL 双重抑制剂，是 BH-3 类似物，对 KPUM-MS3、KPUM-UH1 和 STR-428 细胞，IC50 值分别为 26 nM、17 nM 和 170 nM。

体外活性: AZD4320 shows mostly synergistic, and at least additive, growth inhibitory effects on DEL- and DHL derived cell lines. And it profoundly increases cells undergoing apoptosis in all three cell lines[1]. AZD4320 potently augments the antitumor effect of AZD5153 in double expressing lymphoma (DEL)- and double hit lymphoma (DHL)-derived cell lines in a dose-dependent manner.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 125 mg/mL (132.20 mM)


关键字: Bcl-2 Family | Inhibitor | AZD4320 | AZD 4320 | inhibit | AZD-4320

相关产品: IVHD-valtrate | Bcl-xL antagonist 2 | 2-Methoxystypandrone | (S)-Purvalanol B | WEHI-9625 | TC11 | S55746 hydrochloride | Hinokiflavone | Navitoclax | Paederosidic acid

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Lung Cancer Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | Cuproptosis Compound Library | Preclinical Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途