盐酸苯乙福明 T1453
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 g | 834-28-6 | ¥671.00 | 询底价 |
500 mg | 834-28-6 | ¥291.00 | 询底价 |
1 g | 834-28-6 | ¥418.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Phenformin hydrochloride
描述: Phenformin hydrochloride (Phenformin HCl) 是一种具有抗高血糖活性的双胍类抗糖尿病药物,能够使 AMPK 活化。
激酶实验: Total AMPK activity is measured using the method of Dagher et al. AMPK activity is quantified in the resuspended pellet as incorporation of?32P from [γ-32P]ATP (10 GBq/mmol) into a synthetic peptide with the specific target sequence for AMPK, the SAMS peptide. Radioactivity is measured using a liquid scintillation counter. Protein content in the solution containing the resupended (NH4)2SO4 pellet is determined using the Bradford method.
体外活性: 在小鼠的肺脏和肺肿瘤中,Phenformin能够上调P-eIF2α和其靶标BiP/ Grp78的水平.
体内活性: 在H441细胞中,Phenformin能够增加AMPK活性,同时降低基础离子的转运。在分离的心脏中,Phenformin 增加AMPK活性和磷酸化。在LKB1缺陷型NSCLC细胞系中,Phenformin 能够显著诱导凋亡。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 60 mg/mL (248.22 mM)
H2O : 44 mg/mL (182 mM)
Ethanol : 10 mg/mL (41.4 mM)
关键字: AMPK | Phenethylbiguanide | Phenformin hydrochloride | AMP-activated protein kinase | Autophagy | Inhibitor | inhibit | Phenformin Hydrochloride | Phenformin | Phenethylbiguanide Hydrochloride
相关产品: Margatoxin TFA | Guanfu base A | Ecdysone | Flupirtine maleate | NS3623 | VU591 | CLP290 | κM-Conotoxin RIIIK | Quinine | Jingzhaotoxin-XII
相关库: Drug Repurposing Compound Library | Anti-Cancer Metabolism Compound Library | FDA-Approved & Pharmacopeia Drug Library | Membrane Protein-targeted Compound Library | Anti-Lung Cancer Compound Library | Anti-Metabolism Disease Compound Library | Cancer Cell Differentiation Compound Library | Kinase Inhibitor Library | Traditional Chinese Medicine Monomer Library | Glycolysis Compound Library
盐酸苯乙福明 T1453信息由TargetMol中国为您提供,如您想了解更多关于盐酸苯乙福明 T1453报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途