化合物 T14553 T14553
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
2 mg | 56632-39-4 | ¥845.00 | 询底价 |
5 mg | 56632-39-4 | ¥1,410.00 | 询底价 |
1 mL | 56632-39-4 | ¥1,660.00 | 询底价 |
25 mg | 56632-39-4 | ¥5,820.00 | 询底价 |
100 mg | 56632-39-4 | ¥12,400.00 | 询底价 |
50 mg | 56632-39-4 | ¥7,570.00 | 询底价 |
Product Introduction
Bioactivity
英文名: BHPI
描述: BHPI is a potent inhibitor of nuclear estrogen–ERα-regulated gene expression. Elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), and persistent inhibition of protein synthesis. IC50 value: Target: ERα inhibitor BHPI is effective because it elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), and persistent inhibition of protein synthesis. In ERα(+) cancer cells, BHPI rapidly hyperactivates plasma membrane PLCγ, generating inositol 1,4,5-triphosphate (IP3), which opens EnR IP3R calcium channels, rapidly depleting EnR Ca(2+) stores. BHPI distorts a newly described action of estrogen-ERα: mild and transient UPR activation. In contrast, BHPI elicits massive and sustained UPR activation, converting the UPR from protective to toxic.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 150 mg/mL (452.68 mM)
关键字: BHPI
化合物 T14553 T14553信息由TargetMol中国为您提供,如您想了解更多关于化合物 T14553 T14553报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途