阿卡地新 T1477

Product Introduction
Bioactivity


英文名: AICAR

描述: AICAR (NSC105823) 是一种腺苷类似物，是一种 AMP 激活的蛋白激酶激活剂，可用于治疗急性淋巴细胞白血病和糖尿病。

细胞实验: Acadesine is added to K562 cell lines or primary cells (103 CD34+ cells/mL) growing in semisolid methyl cellulose medium. MethoCult H4100 or H4236 are used for cell lines and primary CD34+ cells respectively. Colonies are detected after 10 days of culture by adding 1 mg/mL of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reagent and are scored by Image J quantification software. (Only for Reference)

体外活性: 在猪体内, Acadesine（10 mg/kg）抑制肺毛细血管中脂多糖诱导的蛋白渗透,

体内活性: 在大鼠肝细胞中, Acadesine（500 μM）能够引起MPK的短暂活化,显着抑制大鼠肝细胞脂肪酸和甾醇的合成,同时引起HMG-CoA还原酶失活。B-CLL细胞中（EC50=380 μM）,Acadesine（0.5 mM）能够诱导B-CLL细胞凋亡并激活AMPK。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 19.4 mg/mL (75 mM)
DMSO : 19.4 mg/mL (75 mM)


关键字: Yes-associated protein | Autophagy | inhibit | AMPK | AICAR | Mitophagy | NSC-105823 | Endogenous Metabolite | NSC 105823 | AMP-activated protein kinase | Mitochondrial Autophagy | YAP | Inhibitor

相关产品: Metformin hydrochloride | Tanespimycin | Torkinib | GSK2578215A | Matrine | Ivermectin | Quercetin | Simvastatin | Kaempferol | ABT-737

相关库: Drug Repurposing Compound Library | FDA-Approved Kinase Inhibitor Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Cancer Drug Library | Anti-Cancer Clinical Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library | Metabolism Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途