氢溴酸西酞普兰 T1483

Product Introduction
Bioactivity


英文名: Citalopram hydrobromide

描述: Citalopram hydrobromide (XU-62-320) 是一种选择性 5-羟色胺再摄取抑制剂，可选择性地抑制 CNS 神经元对 5-羟色胺的再摄取，从而增强中枢神经系统中的 5-羟色胺能活性，也具有抗抑郁活性。它抑制兔血小板中 5-HT 的摄取，IC50为 14 nM。

细胞实验: Cells are cultured in alpha minimum Eagles medium supplemented with 1% penicillin/streptomycin, 10% fetal bovine serum and Amphotericin B. For control data, cells are cultured for 3 or 7 days with standard alpha proliferation media. For SSRI treatments, media is supplemented with citalopram eluted to serially diluted doses between 10?4 mol through 10?10 mol to achieve a dose response curve.(Only for Reference)

体外活性: Citalopram (Lu 10-171), a new bicyclic phthalane derivative, is an extremely potent inhibitor of neuronal serotonin (5-HT) uptake but has no effect on the uptake of noradrenaline(NA) and dopamine (DA) and no antagonistic activity towards 5-HT, histamine, gamma aminobutyric acid (GABA), acetylcholine, and morphine receptors. It is an extremely specific and potent inhibitor of neuronal 5-HT uptake. Uptake mechanisms for other transmitter amines are not influenced by the drug[1]. The SSRI citalopram has a greater effect on proliferation and a lesser effect on apoptotic activity. It affects cell cycle regulation by increasing proliferative potential and decreasing apoptotic activity in a site specific manner that may be indicative of hyperplasia. Citalopram alters FGF, MSX and TGFB expression in osteoblast cell culture[3].

体内活性: Citalopram is devoid of cardiotoxic effects even when animals are exposed to concentrations far above the therapeutic level. In man citalopram is metabolized to compounds which are also potent 5-HT-uptake inhibitors without effect on noradrenaline(NA) uptake and which are found in lower concentrations than citalopram itself. Citalopram (1-16 mg/kg) stimulates the hind limb flexor reflex in the spinal rat. Citalopram potentiates 5-HT transmission~ possibly by producing very strong uptake inhibition without simultaneously blocking the post-synaptic 5-HT receptors[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 6 mg/mL(14.8 mM)
DMSO : 55 mg/mL (135.7 mM)
H2O : 4 mg/mL(9.9 mM)


关键字: Citalopram | SLC6A4 | Citalopram hydrobromide | SERT | serotonin | selective | 5-HTT | Autophagy | 5-HT,Antidepressant | (±)-Citalopram | Citalopram Hydrobromide | reuptake | inhibitor | inhibit | SSRI | Serotonin Transporter

相关产品: Promethazine | SB 243213 hydrochloride | Flesinoxan | Alprenolol hydrochloride | alpha-Yohimbine | Cinchonidine | Urapidil | Ondansetron hydrochloride | A-582941 dihydrochloride | SB-200646A

相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | Anti-Cancer Clinical Compound Library | GPCR Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | NO PAINS Compound Library

氢溴酸西酞普兰 T1483信息由TargetMol中国为您提供，如您想了解更多关于氢溴酸西酞普兰 T1483报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途