化合物C527 T14852

Product Introduction
Bioactivity


英文名: C527

描述: C527 是一种泛 DUB 酶抑制剂，对 USP1/UAF1 复合物具有高效力，IC50值为0.88 μM。

体外活性: C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro. However, the IC50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI and it also lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents[1]. Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC50 of 0.88±0.03 μM. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 1.85 mg/mL (6.31 mM)


关键字: Inhibitor | C527 | DUBs | C 527 | C-527 | Deubiquitinase | inhibit

相关产品: HBX 41108 | USP8-IN-3 | NSC632839 | GNE-6640 | XL177A | FT827 | Vialinin A | USP8-IN-1 | USP30 inhibitor 18 | OTUB1/USP8-IN-1

相关库: HIF-1 Signaling Pathway Compound Library | Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Ubiquitination Compound Library | Inhibitor Library | DNA Damage & Repair Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途