卡泊三醇 T14856

Product Introduction
Bioactivity


英文名: Calcipotriol

描述: Calcipotriol (MC 903) 是一种合成的 VitD3类似物，对维他命 D 受体具有高亲和力。

体外活性: Calcipotriol slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM), when NHEK cells are not stimulated with IL-17A or IL-22. The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2, 20, and 40 nM in a dose-dependent manner [1]. Treatment of natural killer (NK) cells with drugs modulate their expression of NK cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or 1 ng/mL of 1,25(OH)2D3, Calcipotriol or FTY720 for 4 h. All three concentrations of Calcipotriol, 1,25(OH)2D3, and FTY720 significantly up-regulate the expression of NKp30 on the surface of NK cells after 4 h incubation [2].

体内活性: 与安慰剂相比，使用Diclofenac加Calcipotriol治疗的组（p=0.018）和Diclofenac加DFMO加Calcipotriol治疗的组（p=0.002）的体重增长明显减少。生存率在各组之间均等分布。每组中的32只动物中，有一只死亡，除了Diclofenac加DFMO加Calcipotriol组外，该组动物全部存活[3]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (242.37 mM)
Ethanol : 50 mg/mL (121.18 mM)


关键字: Vitamin D receptor | inhibit | MC-903 | VD/VDR | Vitamin D | Calcipotriol | Inhibitor | MC903

相关库: Drug Repurposing Compound Library | Approved Drug Library | Bioactive Compounds Library Max | Human Metabolite Library | NMPA-Approved Drug Library | Pediatric Drug Library | Nuclear Receptor Compound Library | Metabolism Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途