卡奇霉素 T14858

Product Introduction
Bioactivity


英文名: Calicheamicin

描述: Calicheamicin (Calicheamicin γ1) 是肿瘤抗生素，可引起DNA 双链断裂，抑制DNA 合成。

体外活性: PF-06647263 (anti-EFNA4-ADC) is generated via conjugation of hE22 lysine residues to the AcButDMH-N-Ac-calicheamicin-γ1 linker-payload with an average drug-to-antibody ratio (DAR) of 4.6. PF-06647263 elicits antigen- and concentration-dependent cytotoxicity, as exposure to PF-06647263 for 96 hours results in cell death (EC50: ~1 ng/mL) [1].

体内活性: PF-06647263 (0.27, 0.36 mg/kg) results in significant tumor regressions in TNBC xenografts. An ADC comprising a humanized anti-EFNA4 monoclonal antibody conjugated to the DNA-damaging agent calicheamicin achieves sustained tumor regressions in both TNBC and ovarian cancer PDX in vivo [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (73.08 mM)


关键字: ADC Cytotoxin | Calicheamicin r1 | Bacterial | Inhibitor | Apoptosis | Calicheamicin | inhibit | ADC Payload | Calicheamicin gamma1 | Calicheamicin γ 1 | DNA Alkylator/Crosslinker | Calicheamicin γ-1 | Antibiotic

相关库: Anti-Cancer Compound Library | Anti-Cancer Active Compound Library

卡奇霉素 T14858信息由TargetMol中国为您提供，如您想了解更多关于卡奇霉素 T14858报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途