化合物Carboxyamidotriazole Orotate T14871

Product Introduction
Bioactivity


英文名: Carboxyamidotriazole Orotate

描述: Carboxyamidotriazole Orotate (L-651582 Orotate) 是一种可口服的信号转导抑制剂，是Carboxyamidotriazole (CAI) 的乳清酸盐形式。它是一种非电压性钙通道和钙通道介导的信号通路的细胞抑制剂，具有抗癌、抗炎活性和抗血管生成作用。

体外活性: Carboxyamidotriazole Orotate inhibits the phosphorylation of a selected target of Bcr-Abl kinase. Carboxyamidotriazole Orotate (0.1-10 μM; 24-96 hours) inhibits cell proliferation of LAMA84R and K562R cell lines[1]. Tyrosine phosphorylation of CrkL is reduced by 5 μM Carboxyamidotriazole Orotate treatment[1].

体内活性: 在CML异种移植瘤上，Carboxyamidotriazole Orotate（342, 513 mg/kg；i.p.；Q1D×5，进行两轮）展现了抗肿瘤活性[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 5 mg/mL (8.61 mM)


关键字: L651582 | Inhibitor | toxicity | Calcium Channel | L 651582 | Ca2+ channels | Ca channels | leukaemia | inhibit | ovarian | chronic | Carboxyamidotriazole | CAI | Bcr/Abl | L-651582 | cancer | myelogenous | Carboxyamidotriazole Orotate

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相关库: Ion Channel Inhibitor Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Metabolism Compound Library | Orally Active Compound Library | Anti-Cardiovascular Disease Compound Library

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