头孢地嗪 T14922

Product Introduction
Bioactivity


英文名: Cefodizime

描述: Cefodizime 是一种新型头孢菌素抗生素，具有广泛的生物活性。Cefodizime 对肾脏没有毒性且具有良好的耐受性和免疫调节活性，具有抗菌活性，可用于研究呼吸系统和泌尿系统的严重感染。

体外活性: Cefodizime displays modest yet variable inhibitory effects against Citrobacter species, including Citrobacter freundii, and Serratia marcescens. It also inhibits other Gram-negative bacteria, such as Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae, and Neisseria meningitidis. Cefodizime is a bactericidal antibiotic with a strong affinity for penicillin-binding proteins 1A/B, 2, and 3 in E. coli. In vitro, the concentrations of Cefodizime required for bactericidal activity against susceptible strains of both Gram-positive and Gram-negative bacteria are generally comparable to the minimum inhibitory concentrations.[1]

体内活性: Cefodizime (50 mg/kg; S.C.; single; experimentally-induced K. pneumoniae respiratory tract infections in mice) exhibits activity comparable to Cefotaxime and Ceftazidime and surpassing that of Cefoperazone, Latamoxef, Cefuroxime, or cefazolin for the initial 8 hours. In contrast to these cephalosporins, Cefodizime maintains significant bactericidal activity for a duration of at least 48 hours after a single injection. Although Cefodizime can no longer be detected in the serum, it achieves complete bacterial clearance from the lungs within 48 hours in 50% of the mice.[1]

存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 11.69 mg/mL (20 mM)


关键字: Cefodizime

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相关库: Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Bioactive Compound Library

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