化合物 T14926 T14926

Product Introduction
Bioactivity


英文名: Centrinone-B

描述: Centrinone-B (LCR-323) is a potent and highly selective inhibitor of PLK4 (Ki: 0.59 nM).

体外活性: Centrinone-B (0-200 nM) significantly decreases cell viability of PLK4-centriole conjunction melanoma cell lines except for p53 mutant SK-MEL-28, and this effect is via inhibition of PLK4. Centrinone-B slightly binds to Aurora A and Aurora B (Kis: 1239 nM and 5597.14 nM). Centrinone-B exhibits >1000-fold selectivity for Plk4 over Aurora A/B in vitro and does not affect cellular Aurora A or B substrate phosphorylation at concentrations that deplete centrosomes [1]. Inhibition of PLK4 by Centrinone-B also induces apoptosis in human melanoma cell lines [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (39.58 mM)


关键字: Centrinone B | LCR323 | Centrinone-B | LCR 323 | CentrinoneB

相关产品: AKI603 | Tripolin A | CCT129202 | 11α-O-Tigloyl-12β-O-acetyltenacigenin B | TAK-285 | PHA-680632 | NU6140 | Aurora Kinases-IN-4 | TAK-901 | XU1

化合物 T14926 T14926信息由TargetMol中国为您提供，如您想了解更多关于化合物 T14926 T14926报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途