化合物 T14948 T14948
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 743438-45-1 | ¥12,500.00 | 询底价 |
2 mg | 743438-45-1 | ¥1,600.00 | 询底价 |
25 mg | 743438-45-1 | ¥9,620.00 | 询底价 |
5 mg | 743438-45-1 | ¥2,710.00 | 询底价 |
100 mg | 743438-45-1 | ¥17,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Chiglitazar
描述: Chiglitazar is a dual agonist of PPARα/γ (EC50s: 1.2, 0.08, and 1.7 μM for PPARα, PPARγ, and PPARδ).
体外活性: Chiglitazar shows weaker PPARγ activating activity than rosiglitazone, but stronger than pioglitazone. In terms of PPARα activation, Chiglitazar shows a more potent activity than rosiglitazone, pioglitazone, or WY14643 which is a selective PPARα agonist [1].
体内活性: Plasma glucose levels in the MSG rats treated with Chiglitazar or rosiglitazone are significantly reduced compared with the control group treated with the vehicle, after insulin injection. Fasting PI levels are lower in animals treated with Chiglitazar and rosiglitazone than control. Chiglitazar ameliorates the HOMA indices. For IPGTT, at the 30?min after glucose loading, the glucose values in the 5 and 10?mg/kg Chiglitazar and rosiglitazone-treatment groups are significantly lower than those in the vehicle treatment group [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Chiglitazar
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途