化合物 Chloroquinoxaline sulfonamide T14953

Product Introduction
Bioactivity


英文名: Chloroquinoxaline sulfonamide

描述: Chloroquinoxaline sulfonamide is a topoisomerase II alpha/beta poison. It is used to control coccidiosis in poultry, rabbit, sheep, and cattle.

体外活性: Chloroquinoxaline sulfonamide causes dose-dependent protein-DNA cross-links to CV-1 monkey kidney cell chromosomal DNA when drug treatment was terminated by lysis with GuHCl. The Chloroquinoxaline sulfonamide IC50 for CV-1cells, obtained using an MTT cytotoxicity assay, was 1.8 mM. Chloroquinoxaline sulfonamide-induced protein-DNA cross-links in CV-1 cells. Chloroquinoxaline sulfonamide-induced topoisomerase II-DNA cross-links [1]. Chloroquinoxaline sulfonamide inhibits the proliferation of murine B16 melanoma cells, but only when relatively high drug concentrations (1 mM) are used [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: NSC 339004 | NSC339004 | Chloroquinoxaline sulfonamide

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途