西托溴铵 T14966
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 51598-60-8 | ¥8,790.00 | 询底价 |
25 mg | 51598-60-8 | ¥6,760.00 | 询底价 |
2 mg | 51598-60-8 | ¥1,210.00 | 询底价 |
100 mg | 51598-60-8 | ¥13,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Cimetropium Bromide
描述: Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.
体外活性: Cimetropium decreases the labeled ACh release induced by electrical field stimulation under the muscarinic autoinhibition blocked-condition, in the superfusion experiments of the preparation which has been preloaded with labeled choline [2]. Cimetropium has a potent antimuscarinic effect in inhibition of contraction of longitudinal muscle preparations. Cimetropium Bromide behaves as a competitive antagonist of muscarinic-mediated contractions in isolated colonic preparations from both species, with affinity values (pA2) ranging between 7.41 and 7.82 [1].
体内活性: Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration (ID50: 27.9 μg/kg); both tonic and phasic components of contractile response are affected. Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli when administered intravenously to conscious dogs provided with a colonic Thiry fistula. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : 50 mg/mL (114.06 mM)
关键字: DA 3177 | DA3177 | Cimetropium Bromide
相关产品: DMAB-anabaseine dihydrochloride | Thiacloprid | CCMI | Rivastigmine tartrate | ML380 | Tosedostat | Arecoline | Benztropine mesylate | Myrianthic acid | Pregnenolone
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途