化合物CITCO T14973

Product Introduction
Bioactivity


英文名: CITCO

描述: CITCO 是一种咪唑噻唑衍生物，也是一种选择性组成型雄甾烷受体激动剂。它抑制脑肿瘤干细胞的生长和扩增，其 EC50 比孕烷 X 受体为 49 nM

体外活性: CITCO (1-50 μM; 48?hours) results in a dose-dependent inhibition of viable cell count and proliferation in both T98G and U87MG glioma and BTSCs. CITCO (0-25?μM; 48?hours) causes the T98G and U87MG glioma and BTSCs expressing very low levels of CAR protein that increased significantly. CITCO (2.5-10?μM; 48?hours) induces apoptosis in BTSCs in culture in dose dependently, but not in normal astrocytes. CITCO (2.5, 5?μM; 48?hours) induces cell cycle arrest differentially in different BTSCs in culture, but not in normal astrocytes[1].

体内活性: CITCO (intraperitoneal; 25?μg; on days 22, 24, 26, 30 and 36) results a significant decrease in tumour growth. After treatment with 100?μg CITCO, it further decreases to an undetectable level [1].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : insoluble
DMSO : 11 mg/ml (25.19 mM)


关键字: CITCO | Inhibitor | inhibit | Apoptosis

相关产品: Y-27632 | Kahweol | Danshensu | Vamotinib | Galanthamine | Deferoxamine | Obacunone | 3-Dehydrotrametenolic acid | Cholesteryl Hemisuccinate Tris Salt | Zeylenone

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Nuclear Receptor Compound Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途