化合物CMS-121 T14991

Product Introduction
Bioactivity


英文名: CMS-121

描述: CMS-121 是喹诺酮衍生物，对乙酰辅酶 A 羧化酶 1 具有抑制作用，具有口服活性。CMS-121具有保护 HT22 细胞免受缺血和氧化损伤的活性，EC50分别为7 nM 和200 nM。CMS-121具有强大的抗炎，抗氧化，神经保护和肾保护作用。

体外活性: CMS-121 can increase acetyl-CoA in cells. CMS-121 (1 μM; 4 hours; HT22 cells) treatment also increases the phosphorylation of ACC1 at serine 79.[1].

体内活性: CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism. CMS-121 (~20 mg/kg; p.o; daily; for 4 months; female SAMP8 mice) treatment decreases cognitive decline and metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (155.58 mM)


关键字: ACC, Acetyl Coenzyme A Carboxylase | CMS 121 | disease | neuroprotective | inhibit | anti-inflammatory | mitochondrial | Alzheimer's | antioxidative | acetylation | Inhibitor | H3K9 | CMS-121 | Acetyl-CoA Carboxylase | dementia | ACC1

相关产品: PF-05175157 | ND-646 | CP-640186 hydrochloride | Haloxyfop | Olumacostat Glasaretil | TOFA | Tralkoxydim | Quizalofop-P | CP-640186 | Firsocostat

相关库: Antioxidant Compound Library | Anti-Hypertension Compound Library | Oxidation-Reduction Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Obesity Compound Library | Lipid Metabolism Compound Library | Metabolism Compound Library | Orally Active Compound Library | Bioactive Compound Library

化合物CMS-121 T14991信息由TargetMol中国为您提供，如您想了解更多关于化合物CMS-121 T14991报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途