化合物 T15004 T15004

Product Introduction
Bioactivity


英文名: CP-532623

描述: CP-532623, a close structural analog of Torcetrapib, is a CETP inhibitor with highly lipophilic properties. It elevates high-density lipoprotein cholesterol.

体外活性: CP-532623 alters the kinetics of lymph lipid transport and decreases lymph lipid transport in chylomicrons. CP-532623 is highly lymphatically transported (28% of the dose). However, it lymphatic transport is closely correlated with drug affinity for ex-vivo lymph lipoproteins or triglyceride emulsions. But, it has poorly related to solubility in mixtures of lipoprotein core and/or surface lipids [2].

体内活性: CP-532623 (50 mg; p.o.; adult male greyhound dogs) treatment substantially transports into the lymphatic system (>25% dose) in fed and fasted dogs. Lymphatic triglyceride transport is significantly lower in fed dogs administered CP-532623. Food enhances oral bioavailability (from 44 to 58%, respectively) and the proportion of the absorbed dose transports via the lymph (from 61 to 86% and from 68 to 83%, respectively) [3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: CP532623 | CP-532623 | CP 532623

相关产品: Evacetrapib | TAP311 | Granotapide | Dalcetrapib | Implitapide | Obicetrapib | Dirlotapide | Lomitapide | BMS-212122 | Lomitapide Mesylate

化合物 T15004 T15004信息由TargetMol中国为您提供，如您想了解更多关于化合物 T15004 T15004报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途