化合物CU-T12-9 T15017

Product Introduction
Bioactivity


英文名: CU-T12-9

描述: CU-T12-9 是特异性 TLR1/2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。

体外活性: CU-T12-9 directly targets TLR1/2 to initiate downstream signaling.?CU-T12-9 specifically induces TLR1/2 activation, which can be blocked by either the anti-hTLR1 or the anti-hTLR2 antibody, but not the anti-hTLR6 antibody.?By binding to both TLR1 and TLR2, CU-T12-9 facilitates the TLR1/2 heterodimeric complex formation, which in turn activates the downstream signaling.?Fluorescence anisotropy assays revealed competitive binding to the TLR1/2 complex between CU-T12-9 and Pam3CSK4 with a half-maximal inhibitory concentration (IC50) of 54.4 nM.?CU-T12-9 signals through nuclear factor κB (NF-κB) and invokes an elevation of the downstream effectors tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), and inducible nitric oxide synthase (iNOS)[1].?

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 250 mg/mL (690.02 mM)


关键字: obesity | inflammatory | carcinoma | cancer | Toll-like Receptor (TLR) | TLR1/2 | diseases | specific | infectious | bladder | CU-T-12-9 | CUT129 | CU-T12-9 | Inhibitor | breast | asthma | CU T12 9 | inhibit | influenza | pancreatic

相关产品: Leonurine hydrochloride | E6446 | Pam2CSK4 TFA | CU-CPT-9a | SM-324405 | Loxoribine | BMS-905 | Okanin | Afimetoran | BBIQ

相关库: Pyroptosis Compound Library | Immuno-Oncology Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Reprogramming Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途