化合物 T15021 T15021

Product Introduction
Bioactivity


英文名: CV-159

描述: CV-159 is a unique dihydropyridine Ca2+ antagonist with antiinflammatory activities. It has an anti-calmodulin (CaM) action.

体外活性: CV-159 (0.1-10 μM) obviously inhibits TNF-α (10 ng/ml, 24 h)-induced VCAM-1 in SMCs in a concentrationdependent manner. CV-159 (10 μM) inhibits TNF (24 h)-induced expression of e-selectin but not vascular cell adhesion molecule-1 and intercellular adhesion molecule-1.CV-159 (10 μM, 30 min) obviously inhibits the TNF-induced ROS production [1]. CV-159 inhibits TNF (20 min)-induced phosphorylation of JNK, p38, and NF-κB p65 (Ser536) [2].

体内活性: CV-159 decreases the size of the brain infarct after permanent middle cerebral artery (MCA) occlusion. CV-159 (5 and 10 mg/kg, p.o.) gives obviously protection against delayed neuronal death in the hippocampal CA1 region of the rats after 15-min transient forebrain ischemia. CV-159 obviously reduces the increase in the water content of the infarcted cortex induced by MCA occlusion [3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: CV159 | CV 159 | CV-159

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途