化合物DC-05 T15080

Product Introduction
Bioactivity


英文名: DC-05

描述: DC-05 是一种DNMT1的抑制剂，IC50和Kd 值分别为 10.3 和 1.09 μM。

体外活性: DC-05 is a non-nucleoside DNMT1 inhibitor with low micromolar IC50 values and significant selectivity toward other AdoMet-dependent protein methyltransferases.?DC-05 (1.25, 2.5, 5, and 10 μM) effectively inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC-05 displays poor potent activities against DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50: >200, >200, >150, >150, >150, >150, 37.1 μM) [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (260.76 mM)


关键字: Inhibitor | DC 05 | DC05 | DNMTs | DNA Methyltransferase | DNA MTases | DC-05 | inhibit

相关产品: Lomeguatrib | Decitabine | 6-Thioguanine | 5-Methyl-2'-deoxycytidine | 2’-Deoxy-2’-fluoro-β-D-arabinocytidine hydrochloride | Nanaomycin A | RG108 | SW155246 | GSK3685032 | SGI-1027

相关库: Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Target-Focused Phenotypic Screening Library | Reprogramming Compound Library | Methylation Compound Library | Stem Cell Differentiation Compound Library | Histone Modification Compound Library | NO PAINS Compound Library | Chromatin Modification Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途