米格列醇 T1529

Product Introduction
Bioactivity


英文名: Miglitol

描述: Miglitol (BAY1099) 是一种口服抗糖尿病化合物，能够抑制糖复合体分解为葡萄糖。

体内活性: D-cycloserine (DCS) facilitates extinction of conditioned freezing to the light CS when no drug pre-exposure has occurred, but pre-exposure to DCS just prior to conditioning disrupted the facilitation of extinction effect in mice. [1] D-cycloserine (DCS) which has a high affinity for the glycine modulatory site in the NMDA receptor complex modulated memory processing in a dose-dependent manner. DCS also facilitates retention in 'senescence-accelerated mice' in which impairment of learning andmemory increases with age. [2] D-cycloserine (DCS) exhibits facilitated extinction of fear but are able to reacquire fear of that conditioned stimulus (CS) in a similar manner as saline-treated control rats. DCS-treated rats exhibits generalized extinction (i.e., they are less fearful of a non-extinguished CS) in comparison to controls. [3] D-cycloserine (DCS), an antimycobacterial agent known to cross the blood-brain barrier, binds with high affinity to this glycine modulatory site, functions as a positive modulator, and facilitates performance of learningtasks in rats. DCS appears to be a potent cognitive enhancer at doses lower than those required for antibacterial activity. [4] D-cycloserine injections (3.25, 15, or 30 mg/kg) before 30 non-reinforced light exposures dose-dependently enhances extinction but does not influence fear-potentiated startle in rats that does not receive extinction training. [5]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 20.7 mg/mL (100 mM)
DMSO : 20.7 mg/mL (100 mM)


关键字: BAY-1099 | inhibit | BAY 1099 | Inhibitor | Miglitol

相关库: Drug Repurposing Compound Library | Approved Drug Library | Glycometabolism Compound Library | ReFRAME Related Library | Drug-Fragment Library | Selected Plant-Sourced Compound Library | Clinical Compound Library | Inhibitor Library | Alkaloid Natural Product Library | Natural Product Library for HTS

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途