化合物 T15345 T15345

Product Introduction
Bioactivity


英文名: FR-188582

描述: FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).

体外活性: FR-188582 inhibits COX-2 (IC50: 17 nM), in a recombinant human COX enzyme activity. The inhibition of prostaglandin (PG) E2 formation by FR188582 is over 6000 times more selective for COX-2 than COX-1.

体内活性: FR-188582 (0.01-3.2 mg/kg, p.o.) reverses paw edema in adjuvant arthritic rats and displays a therapeutic effect in a dose-dependent manner. For adjuvant-injected paws and adjuvant-uninjected paws, the ED50s values (95% C.L.) are 0.074 (0.00021-0.53) and 0.063 (0.0039-0.31) mg/kg , respectively. The anti-inflammatory effect of FR-188582 is threefold more potent than that of Indomethacin. For adjuvant-injected paws and adjuvant-uninjected paws, the ED50s values (95% C.L.) are 0.24 (0.047-1.8) and 0.20 (0.021-0.79) mg/kg, respectively.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: FR-188582 | FR 188582 | FR188582

相关产品: (S)-(+)-Ibuprofen D3 | Ginsenoside Rg5 | Guaiacol | Indomethacin | Rebamipide | Bufexamac | Aspirin | Indobufen | FR 122047 | Zedoarondiol

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途