反油酸吉西他滨 T15378

Product Introduction
Bioactivity


英文名: Gemcitabine elaidate

描述: Gemcitabine elaidate (CP-4126) 是 Gemcitabine 的亲脂性前药。它通过酯酶转化为 Gemcitabine 以被磷酸化。它具有抗肿瘤活性。

体外活性: Gemcitabine analog Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Gemcitabine 5'-elaidic acid ester shows an enhanced cellular uptake and accumulation, resulting in increased conversion to active metabolites, compared to gemcitabine. This formulation of gemcitabine may be less susceptible to deamination and deactivation by deoxycytidine deaminase. Check for active clinical trials or closed clinical trials using this agent.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 26 mg/mL (49.28 mM)


关键字: anti-tumor | CO101 | inhibit | CP4126 | CP 4126 | Autophagy | Nucleoside Antimetabolite/Analog | Gemcitabine elaidate | CO 101 | Apoptosis | Gemcitabine | Inhibitor | elaidate

相关产品: Declopramide | Bornyl acetate | BX-912 | Droxinostat | WYE-132 | TPCA-1 | Docetaxel | 7,8-Dihydroxyflavone | SRT 2183 | SecinH3

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途