盐酸胰高血糖素 T15389L

Product Introduction
Bioactivity


英文名: Glucagon (1-29), bovine, human, porcine hydrochloride

描述: Glucagon (1-29), bovine, human, porcine hydrochloride 是一种由胰腺 α 细胞产生的多肽激素。它可激活 HNF4α 并促进 HNF4α 磷酸化，促进糖异生。

体外活性: Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis. Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia. Glucagon (100 nM) increases the phosphorylation of HNF4α. Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes [3].

体内活性: Glucagon (20 μg/kg) increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice [4].

存储条件: store at low temperature,keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 10 mM


关键字: Porcine glucagon | peptide | hormone | gluconeogenesis | Inhibitor | pancreatic α | Glucagon (129), bovine, human, porcine hydrochloride | GCGR | inhibit | Glucagon Receptor | Glucagon Hydrochloride | HNF4α | HNF-4 | Glucagon (1-29), bovine, human, porcine | Porcine glucagon Hydrochloride | Glucagon , bovine, human, porcine Hydrochloride | Glucagon (1 29), bovine, human, porcine hydrochloride

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相关库: Anti-Cancer Compound Library | Anti-Metabolism Disease Compound Library | NMPA-Approved Drug Library | Peptide Compound Library | Anti-Diabetic Compound Library | Endocrinology-Hormone Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途