化合物GNF179 T15409
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 1261114-01-5 | ¥3,180.00 | 询底价 |
100 mg | 1261114-01-5 | ¥12,300.00 | 询底价 |
50 mg | 1261114-01-5 | ¥9,270.00 | 询底价 |
1 mg | 1261114-01-5 | ¥996.00 | 询底价 |
10 mg | 1261114-01-5 | ¥4,280.00 | 询底价 |
5 mg | 1261114-01-5 | ¥2,890.00 | 询底价 |
25 mg | 1261114-01-5 | ¥6,830.00 | 询底价 |
Product Introduction
Bioactivity
英文名: GNF179
描述: GNF179 是8,8-二甲基 IP 类似物。 它表现出对多药耐药菌株 W2 的效力,具有良好的体外代谢稳定性和体内口服生物相容性。
体外活性: GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not. GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. Anti-parasitic agent GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 120 mg/mL (280.44 mM)
关键字: GNF 179 | Parasite | inhibit | GNF179 | GNF-179 | Inhibitor
相关产品: Melimine | N-Desethyl amodiaquine dihydrochloride | RE-640 | N-p-trans-Coumaroyltyramine | Amodiaquine | Diminazene Aceturate | Lunasin | Anticancer agent 140 | 5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole | Bitoscanate
相关库: ReFRAME Related Library | Bioactive Compounds Library Max | Anti-Parasitic Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library | Anti-Infection Compound Library
化合物GNF179 T15409信息由TargetMol中国为您提供,如您想了解更多关于化合物GNF179 T15409报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途