化合物ITX3 T15602

Product Introduction
Bioactivity


英文名: ITX3

描述: ITX3 是特异的、无毒的、有活性的、具有选择性的TrioN RhoGEF 抑制剂，IC50 值为 76 μM。 ITX3具有抗癌作用，能抑制trion 介导的GTP 在RhoG 和Rac1上的交换，抑制ngf 介导的PC12细胞神经突的生长和trion 诱导的REF52成纤维细胞结构的形成。

体外活性: TrioN inhibitor In transfected mammalian cells, ITX3 blocked TrioN-mediated dorsal membrane ruffling and Rac1 activation while having no effect on GEF337-, Tiam1-, or Vav2-mediated RhoA or Rac1 activation. ITX3 specifically inhibited endogenous TrioN activity, as evidenced by its ability to inhibit neurite outgrowth in nerve growth factor (NGF)–stimulated PC12 cells or C2C12 differentiation into myotubes [1]. ITX3 repressed the Rac1 activity and dose-dependently up-regulated the E-cadherin protein level in the Tara-KD cells [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 1.8 mg/mL (4.8 mM)


关键字: ITX3 | ITX-3 | ITX 3

相关产品: Azathioprine | SAR407899 | GGTI 2147 | CCG-1423 | CCG-222740 | AZA1 | Digeranyl bisphosphonate | ZINC69391 | Y16 acetate(429653-73-6 free base) | EHop-016

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Active Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途