化合物IU1-47 T15604

Product Introduction
Bioactivity


英文名: IU1-47

描述: IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。

体外活性: IU1-47 stimulates tau degradation principally via the ubiquitin-proteasome system. IU1-47 is essentially inactive on free USP14. IU1-47 (25 μM) antagonizes USP14 deubiquitinating activity and stimulates substrate degradation in vitro. IU1-47 (3 μM, 10, and 30 μM; 48 hours) obviously reduces Tau and phosphatase species Ser-202/Thr-205 levels in murine cortical primary neurons.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 16.67 mg/mL (50.39 mM)


关键字: inhibit | IU1 47 | Deubiquitinase | IU-1-47 | IU1-47 | DUBs | Inhibitor | IU147

相关产品: SJB2-043 | USP7-IN-5 | DUB-IN-1 | IU1-248 | Degrasyn | USP8-IN-2 | P22074 | USP28-IN-3 | USP7-IN-8 | I-138

相关库: HIF-1 Signaling Pathway Compound Library | Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Ubiquitination Compound Library | Inhibitor Library | Highly Selective Inhibitor Library | DNA Damage & Repair Compound Library | Covalent Inhibitor Library | Bioactive Compound Library

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