化合物JH-VIII-157-02 T15612

Product Introduction
Bioactivity


英文名: JH-VIII-157-02

描述: JH-VIII-157-02 是一种 ALK 抑制剂，可抑制棘皮动物微管相关蛋白样 4-ALK (EML4-ALK)，对EML4-ALK G1202R、EML4-ALKwt、EML4-ALK C1156Y、EML4-ALK F1174L 和 EML4-ALK F1174L 的 IC50 均为 2 nM。

体外活性: JH-VIII-157-02 potently inhibits EML4-ALKS1206Y, EML4-ALKG1269A, EML4-ALKL1196M, EML4-ALK1151Tins, and EML4-ALKL1152R with IC50s of 2, 3, 58, 107 and 196 nM, respectively. JH-VIII-157-02 has selectivity at other kinases, including IRAK1, CLK4, RET, RET V804L, RET V804M and IRAK 4 with IC50s of 14 nM, 14 nM, 3 nM, 13 nM, 12 nM, and 465 nM, respectively[1].

体内活性: In mice, JH-VIII-157-02 (10 mg/kg) exhibits good oral bioavailability and penetrates the central nervous system[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (53.70 mM)


关键字: CD246 | Cluster of differentiation 246 | inhibit | Anaplastic lymphoma kinase | Anaplastic lymphoma kinase (ALK) | ALK tyrosine kinase receptor | Inhibitor | JHVIII15702 | JH-VIII-157-02 | JH VIII 157 02

相关产品: S-methyl DM1 | Colcemid | Vinflunine Tartrate | Zagotenemab | Oxfendazole | Podofilox | Tubulysin D | 4'-Demethylepipodophyllotoxin | 10-Deacetyltaxol | Entasobulin

相关库: Microtubule-Targeted Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Tyrosine Kinase Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途