化合物JND3229 T15615

Product Introduction
Bioactivity


英文名: JND3229

描述: JND3229 是一种可逆性的 EGFRC797S 抑制剂，对 EGFRL858R/T790M/C797S、EGFRWT 和 EGFRL858R/T790M 的 IC50 值分别为 5.8、6.8 和 30.5 nM。JND3229 具有较好的抗增殖活性，能有效地抑制体内肿瘤的生长。JND3229 可用于癌症，尤其是非小细胞癌的研究。

体外活性: JND3229 potently inhibits the proliferation of BaF3 cells (harboring the EGFRL858R/T790M/C797S and EGFR19D/T790M/C797Smutations), NCI-H1975 NSCLC cells (with EGFRT790M mutation) and A431 cancer cells (overexpressing EGFRWT) with IC50 values of 0.51, 0.32, 0.31 and 0.27 µM, respectively. JND3229 (0.1, 0.3, 1, 3, 10 µM; 2 h) potently inhibits the phosphorylation of EGFRL858R/T790M/C797S and EGFR19D/T790M/C797S in engineering BaF3 cells[1].

体内活性: JND3229 (10 mg/kg; i.p.; 每日两次，连续10天) 显著抑制肿瘤生长，并在体内展示了靶向抑制作用[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 11.7 mg/mL (19 mM)


关键字: JND3229 | JND-3229 | JND 3229

相关产品: PD153035 | Icotinib | OK2 | Beta-Hydroxyisovalerylshikonin | Rociletinib | AZD8931 diFuMaric acid | DBPR112 | Pelitinib | CGP77675 | RTC-5

相关库: Anti-Breast Cancer Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Anti-Lung Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Anti-Pancreatic Cancer Compound Library

化合物JND3229 T15615信息由TargetMol中国为您提供，如您想了解更多关于化合物JND3229 T15615报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途