化合物 T15690 T15690

Product Introduction
Bioactivity


英文名: L-902688

描述: L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid receptors.

体外活性: L-902688 (1 μM; 24 hours; HUVE cells) treatment, decreases TGF-β-induced Twist and α-smooth muscle actin (α-SMA) expression.

体内活性: In the monocrotaline (MCT)-induced PAH rat model, L-902688 (0.25-1 μg/kg/day; intraperitoneal injection; daily; for 3 weeks; adult male Sprague-Dawley rats) treatment decreases right ventricle fibrosis [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: L902688 | L 902688 | L-902688

相关产品: Beta-Hydroxyisovalerylshikonin | Latifolin | Rutin | Misoprostol | Tafluprost | Rebamipide | Friedelin | Embelin | RO1138452 | 15-keto Prostaglandin F2α

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途