L-甲状腺素钠五水合物 T15699
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 6106-07-6 | ¥150.00 | 询底价 |
1 mL | 6106-07-6 | ¥595.00 | 询底价 |
Product Introduction
Bioactivity
英文名: L-Thyroxine sodium salt pentahydrate
描述: L-Thyroxine sodium salt pentahydrate (Levothyroxine) 是一种合成的甲状腺激素,用于甲状腺功能减退症的研究。
体内活性: L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps, and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. Deiodinases, which catalyze the conversion of thyroxine (pro-hormone) to the active thyroid hormone, is associated with thyroid-stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze the activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play a pivotal role in the negative feedback regulation of pituitary TSH secretion [1]. A significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with a standard diet (p<0.001), in rats fed 12 weeks with the iodine-free diet. An increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19), in the group treated with low doses of L-Thyroxine. Rats treated with high doses of L-Thyroxine show a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03) [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 28 mg/mL (31.50 mM)
关键字: L-Thyroxine sodium salt | LThyroxine sodium salt pentahydrate | L-Thyroxine sodium Pentahydrate | L-Thyroxine sodium | Sodium levothyroxine | Sodium levothyroxine Pentahydrate | THR | Inhibitor | Thyroid Hormone Receptor | inhibit | L Thyroxine sodium salt pentahydrate
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