利马前列素 T15757

Product Introduction
Bioactivity


英文名: Limaprost

描述: Limaprost (17α,20-dimethyl-δ2-PGE1) 是PGE1类似物，也是口服具有活性的血管舒张剂。它能够增加血流量以及减少血小板聚集。它具有抗心绞痛的功能，可用于疼痛的缓解，以及用于研究缺血性症状。

体外活性: Limaprost通过浓度依赖方式抑制IL-1介导的神经生长因子诱导（IC50：70.9 nM human IVD cells）[3]。

体内活性: PGE1 and limaprost exhibited a novel pharmacological action that suppresses NGF expression in human IVD cells, and other prostanoids differentially regulated NGF expression.?Limaprost has been used to treat patients with lumbar spinal stenosis in Japan and was proved to be effective in relieving symptoms.Platelet aggregation, adhesiveness, bleeding time, and thrombocytopenia induced by ADP and collagen infusion in guinea-pigs are inhibited by oral administration of Limaprost at the same doses or doses less than those relieving vasopressin-induced ST depression of ECG.?Intra-coronary injection of Limaprost (1-100 ng/kg) in dogs causes a remarkable increase in coronary blood flow without any influence on heart rate, blood pressure, myocardial oxygen consumption, and redox potential.?Limaprost given orally at more than 100 mg/kg relieves vasopressin-induced ST depression of rat electrocardiogram.?Resistance in both large and small vessels of the dog coronary artery is decreased by intravenous injection of Limaprost (1-3 mg/kg) [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 40 mg/mL (105.12 mM)


关键字: platelet | ADP | Prostaglandin E synthase | aggregation | inhibit | ischaemic | Antianginal | 17alpha,20-dimethyl-delta2-PGE1 | ONO 1206 | OP-1206 | alprostadil | PGE1 | Inhibitor | Limaprost | IL-1 | OP 1206 | adhesion | PGE synthase | atherosclerotic | 17a,20-dimethyl-δ2-PGE1 | vasodilator | ONO-1206

相关产品: CAFESTOL | Bismuth Subsalicylate | Benzydamine hydrochloride | (S)-Flurbiprofen | ETHYL CAFFEATE | Friluglanstat | hPGDS-IN-1 | AT-56 | HPGDS inhibitor 1 | Pranoprofen

相关库: NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途