维库溴铵 T1594

Product Introduction
Bioactivity


英文名: Vecuronium bromide

描述: Vecuronium bromide (ORG NC 45) 是一种合成的中效单季铵盐类固醇和非去极化神经肌肉阻滞剂，具有肌肉松弛活性。

体外活性: Vecuronium inhibits both forms of the muscle-type acetylcholine receptor (IC50: 1-2 nM). Vecuronium combined with methylprednisolone shows additive effects on both receptor forms.[1] Vecuronium interferes with nicotinic processes in the carotid body and inhibits the chemoreceptor neural response to hypoxia. Vecuronium significantly attenuates the increase in CSNA (DeltaCSNA) in response to hypoxia in the carotid body.[2]

体内活性: Vecuronium has a higher biliary clearance than pancuronium in the rats.[3]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 4 mg/mL (6.27 mM)
Ethanol : 93 mg/mL (145.8 mM)
DMSO : 93 mg/mL (145.8 mM)


关键字: ORG NC45 | Vecuronium | Inhibitor | muscle relaxant | neurological disease | ORG NC-45 | nAChR | inhibit | Nicotinic acetylcholine receptors | Vecuronium Bromide | cancer | Vecuronium bromide | nAChR inhibitor

相关产品: Biperiden | Nitrocaramiphen hydrochloride | Nor-benzetimide | Aniracetam | Facinicline hydrochloride | NS 1738 | Cyclomorusin | (Rac)-Sabcomeline HCl | Methylbenactyzium Bromide | Flavoxate hydrochloride

相关库: Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Approved Drug Library | ReFRAME Related Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途