甲基花生四烯酸氟磷酸酯 T15948

Product Introduction
Bioactivity


英文名: MAFP

描述: MAFP (Methyl Arachidonyl Fluorophosphonate) (Methyl Arachidonyl Fluorophosphonate) 是选择性，针对活性位点，不可逆的 cPLA2 和 iPLA2 抑制剂。 MAFP 也是一种有效的不可逆的 anandamide amidase 抑制剂。

体外活性: In a concentration-dependent manner after a 5 min preincubation at 40°C in P388D1 cells, MAFP inhibits iPLA2 (IC50: 5 μM). MAFP is also an inhibitor of anandamide amidase and as a ligand for the CB1 cannabinoid receptor. MAFP shows selectivity towards anandamide amidase for which it is approximately 3000 and 30000-fold more potent than it is towards chymotrypsin and trypsin, respectively. cPLA is a phospholipid hydrolase using the hydroxyl of serine-228 residue as its catalytic nucleophile[1]. MAFP displaces [3H]CP-55940 binding to the CB1 cannabinoid receptor with an IC50 of 20 nM vs 40 nM for anandamide[2].

存储条件: store at low temperature,keep away from moisture,store under nitrogenPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Methyl Acetate : 9.0 mg/mL (24.3 mM)
DMSO : 90.0 mg/mL (242.9 mM)


关键字: MAFP

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