格列吡嗪 T1603

Product Introduction
Bioactivity


英文名: Glipizide

描述: Glipizide (CP 28720) 是一种有效的、具有口服活性的磺酰脲类抗糖尿病试剂 (anti-diabetic agent)，在 2 型糖尿病的研究中具有价值，但不适用于1 型糖尿病。Glipizide 是通过部分阻断郎格汉斯胰岛细胞中 ATP 敏感钾通道 (KATP)发挥活性 。

激酶实验: The activity of caspase-3, -8 and -9 is assessed using the caspase-3, -8 and -9 colorimetric assay kits, respectively. In brief, 1×106?cells in a 60-mm culture dish are incubated with 10 mM Valproic acid for 24 h. The cells are then washed in PBS and suspended in 5 volumes of lysis buffer provided with the kit. Protein concentrations are determined using the Bradford method. Supernatants containing 50 μg total protein are used to determine caspase-3, -8 and -9 activities. The supernatants are added to each well in 96-well microtiter plates with DEVD-pNA, IETD-pNA or LEHD-pNA as caspase-3, -8 and -9 substrates and the plates are incubated at 37°C for 1 h. The optical density of each well is measured at 405 nm using a microplate reader. The activity of caspase-3, -8 and -9 is expressed in arbitrary absorbance units.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 82 mg/mL (184 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)


关键字: type 2 diabetes | sulfonylurea class | Glipizide | K ATP | KcsA | Inhibitor | mellitus | Potassium Channel | CP-28720 | inhibit | K-4024 | ATP-sensitive potassium | CP28720 | pancreatic β | K4024

相关产品: GW9508 | Clobutinol hydrochloride | AVE-0118 | Pinacidil | A2793 | NS8593 hydrochloride | DPO-1 | AmmTX3 TFA | Reserpine | Nigericin sodium salt

相关库: Ion Channel Inhibitor Library | Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Anti-Diabetic Compound Library | Anti-Obesity Compound Library | Anti-Cancer Approved Drug Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途