化合物McMMAF T16031
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 863971-19-1 | ¥4,690.00 | 询底价 |
10 mg | 863971-19-1 | ¥1,870.00 | 询底价 |
5 mg | 863971-19-1 | ¥1,120.00 | 询底价 |
25 mg | 863971-19-1 | ¥3,180.00 | 询底价 |
1 mg | 863971-19-1 | ¥483.00 | 询底价 |
100 mg | 863971-19-1 | ¥6,680.00 | 询底价 |
Product Introduction
Bioactivity
英文名: McMMAF
描述: McMMAF 是一种保护基团共轭的 MMAF。它是一种具有马来酰亚胺基己酰基接头(MC 接头)的 MMAF 衍生物, MMAF 是一种有效的微管蛋白聚合抑制剂。它可与抗体或其他蛋白质或生物聚合物结合。
体外活性: MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). It cannot be used as a drug itself because MMAF is highly toxic. The linker to the monoclonal antibody is stable in extracellular fluid but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 100 mg/mL (108.09 mM)
关键字: inhibit | Inhibitor | McMMAF | Drug-Linker Conjugates for ADC
相关产品: AK301 | EL-102 | Ombrabulin hydrochloride | ABT-751 | CMPF | Cevipabulin | Tubulin polymerization-IN-55 | CID-663143 | LP-261 | Tau-aggregation and neuroinflammation-IN-1
相关库: Microtubule-Targeted Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途