化合物MK-3328 T16094

Product Introduction
Bioactivity


英文名: MK-3328

描述: MK-3328 是对β-淀粉样蛋白 (β-Amyloid)具有很高的亲和力(IC50 为 10.5 nM）,是一种可作为临床评估β-淀粉样斑块负荷的候选 PET 配体。MK-3328是治疗阿尔茨海默病的潜在药物。

体外活性: MK-3328 displays amyloid binding potency balanced with low levels of nonspecific binding.[1]

体内活性: In normal rhesus monkey positron emission tomography (PET) imaging studies, [18F]MK-3328 demonstrates favorable kinetics, exhibiting high brain uptake, and good washout.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Slightly soluble


关键字: MK-3328 | MK3328 | MK 3328

相关库: Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途