莫雷西嗪 T16127
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 31883-05-3 | ¥17,500.00 | 询底价 |
50 mg | 31883-05-3 | ¥13,800.00 | 询底价 |
25 mg | 31883-05-3 | ¥10,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Moricizine
描述: Moricizine is an antiarrhythmia agent which is used primarily for ventricular rhythm disturbances.
体外活性: Moricizine would exert an antiarrhythmic action on atrial myocytes, as well as on ventricular myocytes, by blocking Na+ channels with a high affinity to the inactivated state and slow dissociation kinetics. Moricizine induced the tonic block of INa with the apparent dissociation constant (Kd,app) of 6.3 uM at -100 mV and 99.3 microM at -140 mV. Moricizine works by inhibiting the rapid inward sodium current across myocardial cell membranes. Moricizine at 30 uM shifted the h infinity curve to the hyperpolarizing direction by 8.6 +/- 2.4 mV. Moricizine also produced the phasic block of INa, which was enhanced with the increase in the duration of train pulses, and was more prominent with a holding potential (HP) of -100 mV than with an HP of -140 mV.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Moricizine
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途