化合物MT 63-78 T16156

Product Introduction
Bioactivity


英文名: MT 63-78

描述: MT 63-78 是一种有效的直接AMPK 激活剂，EC50为 25 μM。它诱导细胞有丝分裂阻滞和细胞凋亡，通过抑制脂肪生成和mTORC1途径来阻止前列腺癌的生长，具有抗肿瘤作用。

体外活性: MT 63-78 (0-50 μM; 24 hours; LNCaP, PC3, C4-4, C4-2B, CL1and 22RV1cells) treatment induces reduction of anti-apoptotic Mcl-1 in concert with an accumulation of the pro-apoptotic BH3-only protein Puma. MT 63-78 (0-50 μM; 4 days; LNCaP and PC3 cells) treatment displays a dose-dependent decrease in cell number and concomitant to the activation of AMPK signaling. MT 63-78 (0-50 μM; 30 minutes; LNCaP and PC3 cells) treatment shows dose-dependent phosphorylation of the two major AMPK targets Acetyl-CoA Carboxylase (ACC) on Ser79 and of Raptor on Ser792. And also increases Thr172 phosphorylation on the AMPK α subunit. MT 63-78 (25 μM; 24 hours; LNCaP and CRPC cells) treatment causes a significant enrichment in the G2/M population .

体内活性: MT 63-78（30 mg/kg；腹腔注射；每天；持续14天；C57 BL/6 雄性小鼠）治疗可导致肿瘤生长抑制33%。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.26 mg/mL (10 mM)


关键字: Raptor | mitotic | Mammalian target of Rapamycin | direct | antitumor | mTOR | MT 63-78 | Thr172 | arrest | dephosphorylation | Inhibitor | AMP-activated protein kinase | Mcl-1 | mTORC1 | Apoptosis | AMPK | MT 63 78 | lipogenesis | BH3 | MT 6378 | p53 | inhibit

相关产品: Jaceosidin | MMRi64 | PF-543 | Ginkgolide B | Chelerythrine chloride | CCCP | Pinosylvin | NSC 48160 | INCB-057643 | C646

相关库: Anti-Prostate Cancer Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Oxidation-Reduction Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Epigenetics Compound Library | Anti-Cancer Active Compound Library | Autophagy Compound Library | Glycolysis Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途