化合物MY-5445 T16164

Product Introduction
Bioactivity


英文名: MY-5445

描述: MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) 是特异性的 cGMP 磷酸二酯酶 PDE5抑制剂，其 Ki=1.3 μM。它是一种 ABCG2转运蛋白调节剂，具有抗增殖活性。它能抑制人血小板凝集。

体外活性: in ABCG2-overexpressing cells, MY-5445 selectively reverses ABCG2-mediated multidrug resistance. MY-5445 reverses ABCG2-mediated multidrug resistance (MDR) by potentiating the cytotoxicity of an ABCG2 substrate drug in ABCG2-overexpressing multidrug-resistant cancer cells, possibly by modulating the function and/or the protein expression of ABCG2[2]. In the S1-M1-80 cell, MY-5445 (3 μM; 48 hours) substantially increases the topotecan-induced apoptosis[2].

体内活性: I.p administration of 0.5-3 mg/kg twice a day for 15 days) produces significant relief of mechanical hypersensitivity[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 40 mg/mL (120.55 mM)


关键字: aggregation | platelet | Inhibitor | anticancer | inhibit | neuropathic | MY 5445 | Phosphodiesterase (PDE) | neuropathic pain | allodynia | MY-5445 | MY5445

相关产品: Tanimilast | 3-O-Methylquercetin | Sophoflavescenol | Milrinone | THPP-1 | 2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide | Kushenol K | RS-25344 hydrochloride | CDC801 | Carbazeran

相关库: Anti-Neurodegenerative Disease Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Metabolism Compound Library | Anti-Alzheimer's Disease Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途