化合物 T16272 T16272
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 385800-16-8 | ¥1,980.00 | 询底价 |
1 mL | 385800-16-8 | ¥2,280.00 | 询底价 |
25 mg | 385800-16-8 | ¥8,620.00 | 询底价 |
100 mg | 385800-16-8 | ¥16,200.00 | 询底价 |
50 mg | 385800-16-8 | ¥11,200.00 | 询底价 |
2 mg | 385800-16-8 | ¥1,170.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Naproxen etemesil
描述: Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed.
体外活性: Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is an approximately equipotent inhibitor of COX-1 and COX-2 in intact cells (IC50s: 2.2 μg/mL and 1.3 μg/mL, respectively)[1].
体内活性: Naproxen is shown to inhibit the time-courses of pain, fever, and PGE2 with similar potencies (IC50=27, 40, 13 μM). Naproxen exerts an anti-inflammatory and antifibrotic effect in the mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation [2][3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Naproxen etemesil | MX-1094 | LT-NS001 | LT-NS-001 | MX1094
相关产品: EMD57439 | Deltarasin | GSK256066 | FPFT-2216 | Pimobendan | CALP2 acetate(261969-04-4 free base) | BC 11-38 | RS-25344 hydrochloride | Mirodenafil | Carbazeran
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途