尼多克罗 T16280

Product Introduction
Bioactivity


英文名: Nedocromil

描述: Nedocromil (FPL 59002) 对多种介质的作用或形成有抑制作用，包括组胺，前列腺素 D2和白三烯 C4。

体外活性: Nedocromil通过对抗原挑战的肥大细胞，抑制组胺、LTC4和PGD2的释放，其IC30值分别为2.1 μM、2.3 μM和1.9 μM。同时，它对抗人类IgE亦表现出抑制作用，相应的IC30值为4.7 μM、1.3 μM和1.3 μM[1]。

体内活性: Nedocromil can obviously improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function. Nedocromil-treated diabetic mice display obviously improved heart function compared with controls. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 16.67 mg/mL (44.89 mM)


关键字: Prostaglandin Receptor | FPL59002 | Inhibitor | inhibit | FPL-59002 | Leukotriene Receptor | Nedocromil | Histamine Receptor

相关产品: 5-O-Demethylnobiletin | ONO4057 | Tipelukast | Zafirlukast | Pobilukast | 11-​Keto-​beta-​boswellic acid | LTB4 antagonist 2 | LTB4 antagonist 3 | CGP 35949 | SR 2640 hydrochloride

相关库: Drug Repurposing Compound Library | Neurotransmitter Receptor Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Anti-Cancer Clinical Compound Library | GPCR Compound Library | Pediatric Drug Library | Anti-Cancer Approved Drug Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途