化合物NS5806 T16348

Product Introduction
Bioactivity


英文名: NS5806

描述: NS5806 是钾电流的激活剂，可增加 KV4.3/KChIP2峰值电流幅度，EC50值为 5.3 μM。它会在包含 KChIP2 的通道复合体中降低 KV4.2 和 KV4.3 电流衰减。

体外活性: NS5806 activates canine transient outward potassium current (Ito) (IC50: 40.7 nM and an EC50 of 1.6 nM for inhibition and stimulation on the rabbit, respectively). NS5806 (10-100 nM) has concentration-dependent effects on ventricular and atrial Ito. NS5806 (10 μM) induces a 65% increase of KV4.3/KChIP2/DPP6 peak current amplitudes concentration-dependently and the time course of inactivation (τ) is slowed with an EC50 value of 25.4 μM in CHO-K1 cells[1][2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 250 mg/mL (435.49 mM)


关键字: Potassium Channel | KV4.3 | Inhibitor | KcsA | dacay | peak | KChIP2 | NS 5806 | Ito | KV4.2 | current | inhibit | NS5806 | amplitudes

相关产品: Heteropodatoxin-1 | VU591 hydrochloride | Propafenone | Dihydroberberine | Paederosidic acid methyl ester | Tipepidine hydrochloride | Wilfordine | SKA-111 | TWIK-1/TREK-1-IN-3 | A2764 dihydrochloride

相关库: Ion Channel Inhibitor Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library

化合物NS5806 T16348信息由TargetMol中国为您提供，如您想了解更多关于化合物NS5806 T16348报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途