化合物NSC781406 T16355

Product Introduction
Bioactivity


英文名: NSC781406

描述: NSC781406是一种高效PI3K 和mTOR 抑制剂，其PI3Kα的IC50值为2 nM。

体外活性: NSC781406 shows reasonable liver microsome stability. NSC781406 displays effective PI3K inhibition (PI3Kα IC50=2.0 nM) that translates into BEL-7404 cells proliferation inhibition (IC50=20 nM) and it also demonstrates cytotoxic activities against leukemia, non-small cell, lung cancer, colon cancer, central nervous system cancer, melanoma, ovarian cancer, renal cancer, prostate cancer, and breast cancer. It is effective against 60 cancer cell lines with a mean GI50 value of 65 nM and with a GI50 value of less than 10 nM against four cancer cell lines.

体内活性: NSC781406 is well tolerated at 30 mg/kg, with no observed mortality or significant reduction of body weight. NSC781406(30 mg/kg) treatment, causes statistically significant antitumor activity, in the xenograft models. It has a mean reduction in the relative tumor volume ratio of 52%. Sorafenib shows an inhibition ratio of 44% at 50 mg/kg .

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 150 mg/mL (238.98 mM)


关键字: Phosphoinositide 3-kinase | NSC781406 | PI3K | Mammalian target of Rapamycin | Inhibitor | inhibit | mTOR | NSC 781406 | NSC-781406

相关产品: PI3Kα/mTOR-IN-1 | PI3Kδ-IN-3 | Dalbergioidin | PIK-75 | AZD3458 | IPI-3063 | Oroxin B | mTOR inhibitor 9c | GS-9901 | PF-04979064

相关库: Anti-Aging Compound Library | PI3K-AKT-mTOR Compound Library | Oxidation-Reduction Compound Library | Anti-Cancer Metabolism Compound Library | Glutamine Metabolism Compound Library | Antidepressant Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Colorectal Cancer Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途