化合物 DA-3003-1 T16357
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 383907-43-5 | ¥882.00 | 询底价 |
2 mg | 383907-43-5 | ¥489.00 | 询底价 |
Product Introduction
Bioactivity
英文名: DA-3003-1
描述: DA-3003-1 (DA-3003-1) 是一种可渗透进细胞膜且具有有效性和选择性的 Cdc25 dual specificity phosphatase 抑制剂,具有抗肿瘤活性,对 Cdc25B2、Cdc25A、Cdc25B2 和 Cdc25C具有抑制作用。
体外活性: DA-3003-1(DA-3003-1)(3-100 μM; 48 hours) exhibits an average IC50 value of 1.5 ± 0.6 μM across the NCI 60 cell panel of human tumor types. The IC50 values for human breast cancer MDA-MB-435 and MDA-N cells are 0.2 μM, while in cultured human breast MCF-7 cells, the IC50 value is 1.7 μM[1].The relative IC50 value of DA-3003-1(DA-3003-1) against Cdc25B2 (IC50=0.21 μM) is lower than that against VHR (IC50 20 times lower and 450 times lower than 4.0 μM) or PTP1B (IC50>4.0 μM)[3].
体内活性: DA-3003-1(DA-3003-1)(intravenous injection; 2, 3, and 5 mg/kg) inhibits the growth of subcutaneous human colon HT29 xenografts in SCID mice. Following a single dose of 5 mg/kg, DA-3003-1(DA-3003-1)is undetectable in plasma or tissues for more than 5 minutes. After treatment of HT29 tumor-bearing SCID mice with DA-3003-1(DA-3003-1), a greater reduction in glutathione concentration is observed in the tumor compared to the liver and kidneys, and this decrease persists for a longer duration[1].
存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 60 mg/mL(186.47 mM)
相关产品: EWP 815 | CCT007093 | MB-07729 | LYP-IN-4 | 3-Acetoxy-11-ursen-28,13-olide | CDC25B-IN-2 | IACS-13909 | PTP1B/AKR1B1-IN-2 | JAB-3068 | ML400
相关库: Inhibitor Library
化合物 DA-3003-1 T16357信息由TargetMol中国为您提供,如您想了解更多关于化合物 DA-3003-1 T16357报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途