昂曲托来 T16390

Product Introduction
Bioactivity


英文名: Omtriptolide

描述: Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.

体外活性: Triptolide is a traditional Chinese medicine. It also has anti-inflammatory, antiproliferative, and proapoptotic properties[1].

体内活性: Omtriptolide inhibits fibrosis in the bleomycin group when given the same day or 5 days after bleomycin. Omtriptolide inhibits in vivo both CD4+Vbeta3+ and CD8+Vbeta3+ T cell (alloreactive T cells in this model) expansion in the spleen by 64.09 and 34.02%, respectively, at the time when Vbeta3+ cell expansion is in the logarithmic phase (day 3 after transplantation). Omtriptolide also markedly reduces the number of myofibroblasts in the bleomycin treatment group. Omtriptolide causes a significant decrease in blood urea nitrogen (BUN), serum creatinine, and acute tubular necrosis (ATN) score, and a nonsignificant increase in tubular apoptosis score in AKI, in a mouse model of cisplatin-induced AKI. The protection of Omtriptolide against AKI is associated with a decrease in p-ERK and is independent of MKP-1 and proinflammatory cytokines[1]. Omtriptolide attenuates airway obliteration and inhibits the accumulation of inflammatory cells, and therefore may have preventive or therapeutic benefits for patients with obliterative airway disease following lung transplantation, in a mouse heterotopic tracheal allograft model of obliterative airway disease [2][3][4].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Omtriptolide

相关产品: Morusinol | ERK5-IN-5 | Vincristine | Hirsutenone | XMD8-92 | Endothelin-1 (1-31) (Human) TFA | Epiberberine | Manassantin B | Enniatin B | Rubrofusarin gentiobioside

昂曲托来 T16390信息由TargetMol中国为您提供，如您想了解更多关于昂曲托来 T16390报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途