环丙沙星 T1640

Product Introduction
Bioactivity


英文名: Ciprofloxacin

描述: Ciprofloxacin (Bay-09867) 是一种有高抗菌活性的氟喹诺酮类抗生素。

激酶实验: The in vitro kinase assays is performed by incubating purified kinase (IKKε or TBK1) in kinase buffer containing 25 mM Tris (pH7.5), 10 mM MgCl2, 1 mM DTT, and 10 μM ATP for 30 minutes at 30°C in the presence of 0.5 μCi γ-[32P]-ATP and 1 μg MBP per sample as a substrate. The kinase reaction is stopped by adding 4x sodium dodecyl sulfate (SDS) sample buffer and boiling for 5 minutes at 95°C. Supernatants are resolved by SDS-polyacrylamide gel electrophoresis, transferred to nitrocellulose, and analyzed by autoradiography using a Typhoon 9410 phosphorimager.

体内活性: Ciprofloxacin (1 mg/L) induces GST activity, in contrast with inhibited GST and CAT of larvae exposed to enrofloxacin. Ciprofloxacin (≥10 μg/L) and enrofloxacin are ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae[4]. Ciprofloxacin (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL[2]. In a murine model of pneumonic plague, ciprofloxacin (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in humans following a 500 mg dose of oral ciprofloxacin. Intraperitoneal ciprofloxacin reduces the lung bacterial load compared to controls treated with intraperitoneal PBS[5].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : Insoluble
DMSO : 0.33 mg/mL (1 mM)
0.1 M HCl : 2 mg/mL (6.04 mM)


关键字: Bay 09867 | Bacterial | Apoptosis | Reactive Oxygen Species | anti-proliferative | Inhibitor | mitochondrial | inhibit | ROS | Bay09867 | Antibiotic | Topoisomerase | Mitochondrial Metabolism | DNA damage | DNA | Ciprofloxacin

相关产品: PNU-159682 | Zoliflodacin | SN-38 | Amsacrine hydrochloride | (4-NH2)-Exatecan | Heveaflavone | Rebeccamycin | Tubulin inhibitor 35 | Phenoxodiol | 3-Hydroxysarpagine

相关库: Antibiotics Library | ReFRAME Related Library | Clinical Compound Library | Human Metabolite Library | Pediatric Drug Library | DNA Damage & Repair Compound Library | Anti-Bacterial Compound Library | Orally Active Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途